منابع مشابه
Studies of cellular toxicity of unconjugated bilirubin in kernicteric brain.
Intracerebral deposition of unconjugated bilirubin is believed to be primarily responsible for the neurological manifestations of kernicterus1 (1). Numerous in vitro studies have been carried out on the effect of unconjugated bilirubin on metabolic activity of liver and brain mitochondria (2), brain homogenates (3), cells grown in tissue culture (4, 5), and unicellular organisms (6). The majori...
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Background: Although the bio kinetics, metabolism and chemical toxicity of Atorvastatin are well known, until recently little attention was paid to the potential neurotoxic effect of Atorvastatin (Atv). Regarding the concrete evidences indicating Atv may reduce Coenzyme Q10 (CoQ10) levels through blockage of metalonate cycle, the present work aims to determine if Atorvastatin may provide toxic...
متن کاملHyperbilirubinemia and bilirubin toxicity in the late preterm infant.
Late preterm gestation is an important risk factor for the development of severe neonatal hyperbilirubinemia and kernicterus. An exaggerated hepatic immaturity contributes to the greater prevalence, severity, and duration of neonatal jaundice in late preterm infants. Breast milk feeding is almost uniformly present and large for gestational age status, male sex, and G6PD deficiency are over-repr...
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Background and objectives: Diazinon (DZN), an organophosphate insecticide, is widely used in agriculture. One of its deleterious effects is on neural systems. Diazinon with acetylcholinesterase activity and lipid peroxidation induces brain toxicity . Ginger, as a medicinal plant, has antioxidant and anti-imflammatory properties. The aim of present study was to evaluate...
متن کاملDirect bilirubin higher than total bilirubin?
Both total and direct bilirubin measure the formation of azobilirubin, which is detected at 570/660 nm. The total bilirubin reaction contains surfactant and caffeine, which solubilize “indirect” bilirubin and accelerate the reaction (1). Direct bilirubin is a component of total bilirubin and therefore should always be smaller in value. The presence of a monoclonal immunoglobulin (2220mg/dL) fal...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2001
ISSN: 0743-8346,1476-5543
DOI: 10.1038/sj.jp.7210634